Podcast with Dr. Preeti Kulkarni, N.D. on Weight Loss for Women


“You have the power to make the diet of everyone in your family healthy” -Dr. Preeti

Have you ever thought that women have a harder time losing weight than men? Are there times when you thought your body is just wired differently than others who seem to lose weight easily? There is scientific evidence that may explain this phenomenon and strategies you can follow to overcome it.

Today’s guest is Dr. Preeti Kulkarni. Dr. Preeti is a Naturopathic Doctor, focusing on integrative health. She is the person who was most instrumental in my weight loss transformation and is my go-to expert for health and nutrition information. Please welcome her as she joins us today to answer our questions and give us clear information that we can use to make the best choices for our health.

What You Will Hear In This Episode:

  • Is it harder for women to lose weight?
  • The best way to lose weight when other family members refuse to participate.
  • The importance of a support system during weight loss programs.
  • Interesting ways to keep your healthy foods separate from the unhealthy foods and snacks of other family members.
  • Women’s special weight loss challenges.
  • The weight loss and life transforming benefits of spending time outdoors.
  • Challenges of weight loss after menopause.
  • Accomplishing a healthy equilibrium.
  • What is an obesogen?
  • Learn about your hunger hormones.
  • Obesogens you should avoid, and how to avoid them.
  • Chemical compounds that are banned in Europe but not in the US.

Resources from today’s podcast:

  1. Jensen MD, Ryan DH, Apovian CM, et al. 2013 AHA/ACC/TOS Guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. J Am Coll Cardiol. 2013. [Medline][Full Text].

“As with all chronic medical conditions, effective management of obesity must be based on a partnership between a highly motivated patient and a committed team of health professionals. This team may include the physician, a psychologist or psychiatrist, physical and exercise therapists, dietitians, and other subspecialists, depending on the comorbidities of the individual patient. Scientific evidence indicates that multidisciplinary programs reliably produce and sustain modest weight loss between 5% and 10% for the long-term.”

  1. Nainggolan L. New obesity guidelines: authoritative ‘roadmap’ to treatment. Medscape Medical News. November 12, 2013. [Full Text].
  1. Grün F, Blumberg B. Environmental obesogens: organotins and endocrine disruption via nuclear receptor signaling. Endocrinol. 2006;147(6):S50–S55. http://dx.doi.org/10.1210/en.2005-1129[PubMed]

Bruce Blumberg, a biology professor at the University of California, Irvine, coined the term “obesogen” in 2006 when he discovered that tin-based compounds known as organotins predisposed laboratory mice to gain weight

Blumberg was studying endocrine disruptors in the early 2000s when he heard at a meeting in Japan that TBT causes sex reversal in multiple fish species. “I decided to test whether TBT activated known nuclear receptors, expecting it to activate a sex steroid receptor,” Blumberg says. Instead, it activated peroxisome proliferator–activated receptor gamma (PPARγ), the master regulator of adipogenesis, the process of creating adipocytes, or fat cells.23PPARγ is evolutionarily conserved between mice and humans, and it may be particularly susceptible to chemical “imposters” because it has a large ligand-binding pocket that can accommodate many chemical structures. When a molecule capable of activating the receptor enters the pocket, it turns on the adipogenic program.

See https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3279464/#r18

  1. Klok MD1Jakobsdottir SDrent ML The role of leptin and ghrelin in the regulation of food intake and body weight in humans: a review. Obes Rev. 2007 Jan;8(1):21-34.
  1. Gao Q1Horvath TL. Cross-talk between estrogen and leptin signaling in the hypothalamus.Am J Physiol Endocrinol Metab.2008 May;294(5):E817-26. doi: 10.1152/ajpendo.00733.2007. Epub 2008 Mar 11.
  1. Brown LM1Gent LDavis KClegg DJ.Metabolic impact of sex hormones on obesity.Brain Res.2010 Sep 2;1350:77-85. doi: 10.1016/j.brainres.2010.04.056. Epub 2010 May 23.
  1. Mags E Beksinska; Jenni A Smit; Franco Guidozzi Weight Change and Hormonal Contraception: Fact and Fiction Expert Review of Obstetrics & Gynecology
  1. James P. Grantham, Maciej Henneberg The Estrogen Hypothesis of Obesity Published: June 10, 2014 http://dx.doi.org/10.1371/journal.pone.0099776
  1. Ball K1Brown WCrawford D. Who does not gain weight? Prevalence and predictors of weight maintenance in young women. Int J Obes Relat Metab Disord.2002 Dec;26(12):1570-8.

– Eric O’Grey